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A high-fat diet decreases GABA concentration in the frontal cortex and hippocampus of rats Biol. Res.
Sandoval-Salazar,Cuauhtemoc; Ramírez-Emiliano,Joel; Trejo-Bahena,Aurora; Oviedo-Solís,Cecilia I.; Solís-Ortiz,Martha Silvia.
BACKGROUND: It has been proposed that the γ-aminobutyric acid (GABA) plays a key role in the regulation of food intake and body weight by controlling the excitability, plasticity and the synchronization of neuronal activity in the frontal cortex (FC). It has been also proposed that the high-fat diet (HFD) could disturb the metabolism of glutamate and consequently the GABA levels, but the mechanism is not yet clearly understood. Therefore, the aim of this study was to investigate the effect of a HFD on the GABA levels in the FC and hippocampus of rats RESULTS: The HFD significantly increased weight gain and blood glucose levels, whereas decreased the GABA levels in the FC and hippocampus compared with standard diet-fed rats CONCLUSIONS: HFD...
Tipo: Journal article Palavras-chave: Obesity; GABA; Frontal cortex; Hippocampus; High-fat diet.
Ano: 2016 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602016000100015
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A reassessment of the role of serotonergic system in the control of feeding behavior Anais da ABC (AABC)
Medeiros,Magda A.; Costa-e-Sousa,Ricardo H.; Olivares,Emerson L.; Côrtes,Wellington S.; Reis,Luís C..
The role of serotonergic system in the feeding behaviorwas appraised by electrolytic lesions in the dorsal raphe nucleus (DRN) and administration of para-chlorophenylalanine (PCPA, 3 mg/5 mul, icv). Chronic evaluations were accomplished through 120 and 360 days in PCPA-injected and DRN-lesioned rats, respectively. Acute food intake was evaluated in fasted rats and submitted to injection of PCPA and hydroxytryptophan (LHTP, 30 mg/kg, ip). DRN-lesioned rats exhibited 22-80% increase in food intake up to sixth month, whereas the obesity was evident and sustained by whole period. In PCPA-injected rats was observed an initial increase in the food intake followed by hypophagy from 25th to 30th day and a transitory increase of body weight from 5th to 60th day. In...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Food ingestion; Serotonergic system; Dorsal raphe nucleus; Electrolytic lesion; Para-chlorophenylalanine; Obesity.
Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652005000100008
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A weight loss protocol and owners participation in the treatment of canine obesity Ciência Rural
Carciofi,Aulus Cavalieri; Gonçalves,Karina Nogueira Venturelli; Vasconcellos,Ricardo Souza; Bazolli,Rodrigo Sousa; Brunetto,Márcio Antonio; Prada,Flávio.
The success of a weight loss program for pets depends on the owners collaboration. Their compliance is fundamental in establishing the correct food management. The objective of this study was to compare the effectiveness of a weight loss program in two groups of dogs, one maintained under experimental conditions and the other with their owners. The same hypocaloric food was used to feed all animals, the amount being restricted to 60% of the estimated maintenance energy requirement for a 15% reduction of the present body weight of the dog. The animals were followed during 90 days. A standard questionnaire was used to study the owners' perception of obesity and its treatment. The protocol and the diet were found to be effective. The control dogs had an...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Dogs; Obesity; Treatment; Diet.
Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782005000600016
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Abnormal subcellular distribution of GLUT4 protein in obese and insulin-treated diabetic female dogs BJMBR
Vargas,A.M.; Barros,R.P.A.; Zampieri,R.A.; Okamoto,M.M.; de Carvalho Papa,P.; Machado,U.F..
The GLUT4 transporter plays a key role in insulin-induced glucose uptake, which is impaired in insulin resistance. The objective of the present study was to investigate the tissue content and the subcellular distribution of GLUT4 protein in 4- to 12-year-old control, obese and insulin-treated diabetic mongrel female dogs (4 animals per group). The parametrial white adipose tissue was sampled and processed to obtain both plasma membrane and microsome subcellular fractions for GLUT4 analysis by Western blotting. There was no significant difference in glycemia and insulinemia between control and obese animals. Diabetic dogs showed hyperglycemia (369.9 ± 89.9 mg/dl). Compared to control, the plasma membrane GLUT4, reported per g tissue, was reduced by 55% (P...
Tipo: Info:eu-repo/semantics/other Palavras-chave: Diabetes; Obesity; Insulin resistance; GLUT4; Adipose tissue; Plasma membrane.
Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004000700020
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Access to Local Agriculture and Weight Outcomes AgEcon
Berning, Joshua P..
Recent studies examine the impact of the built environment on health outcomes such as obesity. Several studies find for certain populations that access to unhealthy food has a positive effect on obesity, whereas access to healthy choices has a negative effect. Given the growth and popularity of locally grown food, we examine how individual weight outcomes are affected by access to direct-to-consumer local food. After controlling for potential endogeneity, we find that greater access to local food has a negative association with individual weight outcomes. We also find a negative association with greater weight loss over a one-year period. These results provide evidence that local food access can have potential indirect benefits.
Tipo: Article Palavras-chave: Local agriculture; Obesity; Food access; Food Consumption/Nutrition/Food Safety; Health Economics and Policy.
Ano: 2012 URL: http://purl.umn.edu/123313
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Accounting for Product Substitution in the Analysis of Food Taxes Targeting Obesity AgEcon
Miao, Zhen; Beghin, John C.; Jensen, Helen H..
We extend the existing literature on food taxes targeting obesity. First, we incorporate the implicit substitution between sugar and fat nutrients implied by a complete food demand system and by conditioning on how food taxes affect total calorie intake. Second, we propose a methodology that accounts for the ability of consumers to substitute leaner low-fat and low-sugar items for rich food items within the same food group. This substitution is integrated into a demand system in addition to substitution among food groups. Simulations of a tax on added sugars show that the impact of the tax on consumption patterns is understated and the effect on welfare loss overstated when abstracting from this substitution within food groups.
Tipo: Working or Discussion Paper Palavras-chave: Discretionary calories; Fat; Food demand; Health policy nutrition; Low-fat; Low-sugar substitutes; Obesity; Sugar; Sweeteners; Tax.; Agricultural and Food Policy; Consumer/Household Economics; Demand and Price Analysis; Food Consumption/Nutrition/Food Safety.
Ano: 2010 URL: http://purl.umn.edu/97927
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Accounting for Product Substitution in the Analysis of Food Taxes Targeting Obesity AgEcon
Miao, Zhen; Beghin, John C.; Jensen, Helen H..
We extend the existing literature on food taxes targeting obesity. First, we incorporate the implicit substitution between sugar and fat nutrients implied by a complete food demand system and by conditioning on how food taxes affect total calorie intake. Second, we propose a methodology that accounts for the ability of consumers to substitute leaner low-fat and low-sugar items for rich food items within the same food group. This substitution is integrated into a demand system in addition to substitution among food groups. Simulations of a tax on added sugars show that the impact of the tax on consumption patterns is understated and the effect on welfare loss overstated when abstracting from this substitution within food groups.
Tipo: Conference Paper or Presentation Palavras-chave: Discretionary calories; Fat; Food demand; Health policy nutrition; Low-fat; Low-sugar substitutes; Obesity; Sugar; Sweeteners; Tax; Agricultural and Food Policy; Demand and Price Analysis; Food Consumption/Nutrition/Food Safety; Health Economics and Policy; I18; Q18.
Ano: 2011 URL: http://purl.umn.edu/103320
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Adiponectin promoter polymorphisms are predictors of lipid profile improvement after bariatric surgery Genet. Mol. Biol.
Gasparotto,Aline Simas; Borges,Diego Olschowsky; Zandoná,Marília Remuzzi; Ramos,Mauricio Jacques; Meihnardt,Nelson Guardiola; Mattevi,Vanessa S..
Abstract Our aim was to investigate if single nucleotide polymorphisms (SNPs) located in the 5′ regions of leptin (LEP, -2548 G > A, rs7799039), resistin (RETN, -420 C > G, rs1862513) and adiponectin (ADIPOQ, -11391 G > A, rs17300539 and -11377 C > G, rs266729) genes were related to changes in body mass index (BMI) and metabolic variables after bariatric surgery in 60 extremely obese individuals. At baseline, ADIPOQ -11391 A-allele carriers showed higher plasma adiponectin and lower total cholesterol levels when compared to G/G homozygotes. Approximately 32 months post-surgery, a mean reduction of 35% in BMI and an important improvement in metabolic profiles were observed. In addition, for the ADIPOQ -11377 polymorphism, a higher decrease in...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Adiponectin; Polymorphism; Obesity; Lipid profile; Bariatric surgery.
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572017000500736
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Adiponectin serum levels in female dogs bearing mammary gland carcinomas Arq. Bras. Med. Vet. Zootec.
Souza,I.B.R.; Cardoso,C.V.; Pereira,A.A.F.; Poppe,S.C.; Bondan,E.F..
RESUMO Em seres humanos, a adiponectinemia está associada à obesidade e ao risco aumentado a uma ampla variedade de cânceres. Embora o papel dessa adipocina esteja bem documentado na patogênese do câncer em humanos, tal associação permanece a ser determinada em cães. Nesses animais, a relação da adiponectina com a carcinogênese parece ser ainda meramente especulativa. Nesse contexto, buscou-se nesta investigação comparar os níveis séricos de adiponectina em fêmeas hígidas e em portadoras de carcinomas mamários com diagnóstico histopatológico de carcinoma mamário tubular simples estágio 4, com comprometimento de linfonodos, porém sem metástases a distância detectadas. Foi observado que as cadelas diagnosticadas com carcinoma mamário tiveram níveis séricos...
Tipo: Info:eu-repo/semantics/other Palavras-chave: Dogs; Adiponectin; Cancer; Mammary gland; Obesity.
Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352019000501741
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An Economic Analysis of the Impact of Food Prices and Other Factors on Adult Lifestyles: Choices of Physical Activity and Healthy Weight AgEcon
Chen, Yanni; Huffman, Wallace E..
This paper examines women’s and men’s decisions to participate in physical activity and to attain a healthy weight. These outcomes are hypothesized to be related to prices of food, drink and health care services and products, the respondent’s personal characteristics (such as education, reading food labels, adjusted family income, opportunity cost of time, occupation, marital status, race and ethnicity) and his or her BMI at age 25. These decisions are represented by a trivariate probit model that is fitted to data for adults in the NLSY79 panel with geocodes that have been augmented with local area food, drink and health care prices. Separate analyses are undertaken for men and women due to basic physiological differences. Results include: Women and men...
Tipo: Conference Paper or Presentation Palavras-chave: Physical Activity; Obesity; Food Prices; Adult; United States; Consumer/Household Economics; Health Economics and Policy; Labor and Human Capital; I10; D10; J24.
Ano: 2009 URL: http://purl.umn.edu/49291
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An Economic Analysis of the Impact of Food Prices and Other Factors on Adult Lifestyles: Choices of Physical Activity and Healthy Weight AgEcon
Chen, Yanni; Huffman, Wallace E..
This paper examines women’s and men’s decisions to participate in physical activity and to attain a healthy weight. These outcomes are hypothesized to be related to prices of food, drink and health care services and products, the respondent’s personal characteristics (such as education, reading food labels (signaling a concern for good health), adjusted family income, opportunity cost of time, occupation, marital status, race and ethnicity) and his or her BMI at age 25. These decisions are represented by a trivariate probit model that is fitted to data for adults in the NLSY79 panel with geocodes that have been augmented with local area food, drink and health care prices. Separate analyses are undertaken for men and women due to basic physiological...
Tipo: Conference Paper or Presentation Palavras-chave: Physical activity; Obesity; Food prices; Adults; Developed country; Consumer/Household Economics; Food Consumption/Nutrition/Food Safety; I10; D10; J24.
Ano: 2009 URL: http://purl.umn.edu/49987
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An empirical comparison of atypical bulimia nervosa and binge eating disorder BJMBR
Fontenelle,L.F.; Mendlowicz,M.V.; Moreira,R.O.; Appolinario,J.C..
The International Classification of Diseases, 10th edition (ICD-10) defines atypical bulimia nervosa (ABN) as an eating disorder that encompasses several different syndromes, including the DSM-IV binge eating disorder (BED). We investigated whether patients with BED can be differentiated clinically from patients with ABN who do not meet criteria for BED. Fifty-three obese patients were examined using the Structured Clinical Interview for DSM-IV and the ICD-10 criteria for eating disorders. All volunteers completed the Binge Eating Scale (BES), the Beck Depression Inventory, and the Symptom Checklist-90 (SCL-90). Individuals fulfilling criteria for both ABN and BED (N = 18), ABN without BED (N = 16), and obese controls (N = 19) were compared and contrasted....
Tipo: Info:eu-repo/semantics/other Palavras-chave: Atypical bulimia nervosa; Binge eating disorder; Anxiety; Obesity.
Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005001100014
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An Experimental Investigation of the Impact of Fat Taxes: Prices Effects, Food Stigma, and Information Effects on Economics Instruments to Improve Dietary Health AgEcon
Cash, Sean B.; Lacanilao, Ryan D.; Adamowicz, Wiktor L.; Raine, Kim.
There is currently no published research on how food taxes may affect consumer behaviour when the imposition of the tax itself may be considered a source of consumer information. The work undertaken here seeks to address this gap in the literature by using experimental methods to enhance understanding on the joint effects of price changes induced by a fat tax and the stigma associated with the application of the tax. First, we conduct an interdisciplinary literature review (drawing from economics, psychology, and health promotion) and theoretical investigation of the impact of stigma on economic choice behaviours. We then employ Attribute-Based Stated Choice Methods (ABSCM) to elicit consumer response to fat tax scenarios that rely only on price changes,...
Tipo: Report Palavras-chave: Obesity; Health policy; Fat taxes; Warning labels; Choice experiments; Agribusiness; Agricultural and Food Policy; Consumer/Household Economics; Demand and Price Analysis; Food Consumption/Nutrition/Food Safety; I18; Q18.
Ano: 2008 URL: http://purl.umn.edu/45499
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An International Comparison of the Effects of Government Agricultural Support on Food Budget Shares AgEcon
Miller, J. Corey; Coble, Keith H..
This study evaluates econometrically the effect of government support to agriculture on a measure of the affordability of food in 10 Organization for Economic Cooperation and Development (OECD) countries. The panel model we construct specifically utilizes two values calculated by the OECD: Producer Support Estimates as a percentage of gross farm receipts and the Consumer Nominal Protection Coefficient. These two variables represent transfers from taxpayers to agricultural producers through government programs and transfers from consumers to government through protectionist measures, respectively. By using dummy variables, we find implications for groups of countries on the basis of their relative levels of support and protection.
Tipo: Journal Article Palavras-chave: Agricultural policy; Obesity; Agribusiness; Agricultural and Food Policy; Food Consumption/Nutrition/Food Safety; I18; Q18.
Ano: 2008 URL: http://purl.umn.edu/47196
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Anti-obesity Effects of the Administration of Tournefortia paniculata Cham Extract on Wistar Rats Subjected to a Hypercaloric Diet BABT
Simão,Anderson Assaid; Ramos,Vinicius de Oliveira; Corrêa,Angelita Duarte; Sousa,Raimundo Vicente de; Marcussi,Silvana.
The aim of this study was to evaluate the therapeutic and toxicologic effects of the administration of the powered vegetable extract and aqueous extract of Tournefortia paniculata leaves on Wistar rats, subjected to a hypercaloric diet for 42 days. The rats were divided into five groups and were given the following treatments by gavage: T0 (control) - 1.0 mL water day-1; T1 - aqueous extract containing 14 mg phenolic compounds kg-1 rat day-1; T2 - 14 mg quercetin kg-1 rat day-1; T3 - 50 mg powered vegetable extract from T. paniculata leaves (PVE) kg-1 rat day-1 and T4 - 100 mg PVE kg-1 rat day-1. The treatments did not significantly alter the weight, but were effective in reducing liver fat, glucose and serum triglycerides. The treatment T1 reduced food...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Obesity; Medicinal plants; Pharmacology; Antioxidants; Genotoxicity.
Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132015000400494
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Aqueous extract of Psidium guajava leaves: phenolic compounds and inhibitory potential on digestive enzymes Anais da ABC (AABC)
SIMÃO,ANDERSON A.; MARQUES,TAMARA R.; MARCUSSI,SILVANA; CORRÊA,ANGELITA D..
ABSTRACT Leaves of Psidium guajava L. (guava) have been widely used in the popular way for prevention and treatment of various diseases. Thus, the objective of this study was to evaluate the inhibitory potential of leaves aqueous extract from three cultivars of P. guajava (Pedro Sato, Paluma and Século XXI) on α-amylase, α-glycosidase, lipase, and trypsin enzymes, in the presence or not of simulated gastric fluid and to determine the content of phenolic compounds by high performance liquid chromatography. All cultivars presented the same composition in phenolic compounds, but in different proportions. The compounds identified are gallic acid, epigallocatechin gallate, syringic acid, o-coumaric acid, resveratrol, quercetin, and catechin (which was the major...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Medicinal plants; Obesity; Α-amylase; Α-glycosidase; Lipase; Trypsin.
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000502155
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Are Restaurants Really Supersizing America? AgEcon
Anderson, Michael L.; Matsa, David A..
Replaced with revised version Feb. 24, 2010.
Tipo: Working or Discussion Paper Palavras-chave: Economics of regulation; Health production; Obesity; Fat tax; Food Consumption/Nutrition/Food Safety; Health Economics and Policy; D12; H25; I12; I18.
Ano: 2007 URL: http://purl.umn.edu/37652
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Argyrophil cell density in the oxyntic mucosa is higher in female than in male morbidly obese patients BJMBR
Maksud,F.A.N.; Kakehasi,A.M.; Barbosa,A.J.A..
Obesity is a multifactorial disorder often associated with many important diseases such as diabetes, hypertension and other metabolic syndrome conditions. Argyrophil cells represent almost the total population of endocrine cells of the human gastric mucosa and some reports have described changes of specific types of these cells in patients with obesity and metabolic syndrome. The present study was designed to evaluate the global population of argyrophil cells of the gastric mucosa of morbidly obese and dyspeptic non-obese patients. Gastric biopsies of antropyloric and oxyntic mucosa were obtained from 50 morbidly obese patients (BMI >40) and 50 non-obese patients (17 dyspeptic overweight and 33 lean individuals) and processed for histology and Grimelius...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Argyrophil cells; Endocrine cells; Obesity; Gastric mucosa; Metabolic syndrome.
Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013000400339
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Association Between Exercise and Treatment with Liraglutide in Obese Rats by Cafeteria Diet BABT
Didek,Daiane; Cordeiro,Maiara Mikuska; Xavier,João Lucas de Paula; Ribeiro,Paulo Roberto; Rentz,Thiago; Franco,Gilson Cesar Nobre; Kanunfre,Carla Cristine; Emilio,Henriette Rosa de Oliveira; Scomparin,Dionízia Xavier.
Abstract The objective of this study was to evaluate the effect of liraglutide, an analog of glucagon-like peptide-1 (GLP-1) in association with physical exercise, on the metabolic and biochemical parameters of rats induced to obesity with a cafeteria diet. Male Wistar rats, aged 21 days, were randomly divided into: Controls (CON) receiving standard feed and water ad libitum; and obese (OBESE) receiving cafeteria diet ad libitum, added to the standard diet. Groups were then subdivided into: Liraglutide animals that received subcutaneous injections of liraglutide from 80 to 90 days of life; exercised (EXE) animals submitted to swimming sessions, three days a week (15 min); and liraglutide + EXE animals that received liraglutide in association with physical...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Obesity; Liraglutide; GLP-1; Metabolic syndrome; Exercise.
Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132019000100305
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Association between syndecan-1 and renal function in adolescents with excess weight: evidence of subclinical kidney disease and endothelial dysfunction BJMBR
Saboia,Z.M.R.M.; Meneses,G.C.; Martins,A.M.C.; Daher,E.F.; Silva Junior,G.B..
Excess weight (overweight and obesity) is associated with kidney and cardiovascular disease. The aim of this study was to investigate the association between syndecan-1 and renal function among adolescents with excess weight. A total of 56 students from a public school at Fortaleza, CE, Brazil, were investigated. The adolescents were submitted to anthropometric evaluation, including weight, height, blood pressure and body mass index. Blood and urine samples were collected for the determination of serum lipids (total cholesterol, high density lipoprotein cholesterol, low density lipoprotein cholesterol, triglycerides), and the endothelial injury biomarker syndecan-1. Participants' mean age was 16±1 years (range 14-19 years), and 68% were females. Overweight...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Obesity; Overweight; Biomarkers; Kidney disease; Endothelium; Adolescents.
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018000300606
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